Is it possible to carry twins from two different fathers




















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Wrinkle's owner shared her triumphant running videos on TikTok and YouTube , which highlight Wrinkle's daily doings, and people have been sharing them with great joy on social media. Who can blame them? Ducks are adorable. Ducks in shoes are super adorable. Heteropaternal superfecundation is an extremely rare phenomenon that occurs when a second ova released during the same menstrual cycle is additionally fertilized by the sperm cells of a different man in separate sexual intercourse.

The following analyses were performed: amelogenin gene, autosomal short tandem repeat STR , and Y-STR analyses by means of human identification commercial kits, paternity index, and the probability of paternity calculation and interpretation. A paternity index of 2. The results indicated that the twins have different biological fathers. Although heteropaternal superfecundation is rarely observed among humans given its low frequency, in paternity disputes for dizygotic twins it is mandatory to demand the presence of the two twins in the testing to avoid wrong conclusions.

Heteropaternal superfecundation is an extremely rare phenomenon that occurs when a second ova released during the same menstrual cycle is additionally fertilized by the sperm cells of a different man in separate sexual intercourse taking place within a short period of time from the first one 1 - 4. Wenk, et al. Nevertheless, the frequency of these cases may vary depending on the population's coital rates and double ovulation rates 3.

This phenomenon was initially presented by Archer in 7 ; he showed the phenotypic differences between a white female twin and the other mulatto female twin and his study was later followed by Terasaki, et al. Today, about 19 heteropaternal superfecundation cases worldwide have been reported 2 , 4 , 7 - It has been suggested that this will cease to be a rare event, as cases are being and will be described more frequently thanks to the current availability of molecular methods and the popularity and increasing number of paternity tests 2 - 4 , 14 , In Colombia, Bravo-Aguilar presented a case of heteropaternal superfecundation as an example in the book "The genetic truth of the paternity" where two cases detected in the laboratory are mentioned, but no further information is given Here we present a case of dizygotic twins from different fathers detected in Colombia as evidenced by autosomal short tandem repeat STR DNA markers.

Both twins were males, born after 35 weeks of gestation; the first male was 1, g and the second one, 2, g. The mother denied receiving blood transfusions during pregnancy, but she mentioned oral contraceptive intake before conception and antecedents of twins on her mother's side. The study was conducted with written consent from both the twins' mother and the alleged father.

They also gave their consent for the publication of this work. Blood samples were collected from the twins, their mother, and the alleged father on FTA cards.

We obtained two independent samples for each person taken at different times and each sample was investigated in duplicate. Discrepancies in 14 autosomal STR markers and in 14 STR loci for Y chromosome table 1 between the alleged father and twin 1 were observed.

Results favored the paternity of the alleged father for only one of the twins whom we labeled as 'twin 2. All 21 autosomal and 17 Y-chromosomal markers were in concordance with paternity table 1. The paternity index was 2. As the genetic profile of the undoubted biological mother was available, the autosomal genotyping results indicated that the two twins had different fathers, which was confirmed with Y STR markers. Few cases of heteropaternal superfecundation have been reported worldwide possibly because not all the cases have been involved in paternity disputes, which decreases the probability of their reporting 3 , 5 , However, the frequency of cases will probably rise with time due to the availability of molecular techniques that serve as a tool for the correct resolution of such cases, as well as the recent increase in twin births 2.

In this case, the two brothers participated in the paternity study in response to a preview communication from the laboratory support service explaining that the test required the presence of both twins to study each of them separately, as well as the importance of including the mother.

We observed 14 alleged father-twin 1 incompatibilities for Y-STRs loci table 1 while no discrepancies between the alleged father and twin 2 were found allowing us to link twin 2 to the same paternal linage of the alleged father and to exclude twin 1 relationship to him. National Library of Medicine. Genetics Home Reference. Is the probability of having twins determined by genetics? Updated July 7, How Frequent is Heteropaternal Superfecundation?

Acta Genet Med Gemellol Roma. Challenge to the assumed rarity of heteropaternal superfecundation: Findings from a case report. Aust J Forensic Sci. Paddock C. Curry A. The world's least alike twins. NBC News. Prenat Diagn. Risk of miscarriage following amniocentesis or chorionic villus sampling: Systematic review of literature and updated meta-analysis.

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Cleveland Clinic. DNA Paternity Test. Join now to personalize. Photo credit: iStock. Twins with different fathers: is it common?

How heteropaternal superfecundation occurs Heteropaternal superfecundation, or when twins have different fathers, is actually extremely rare. Paternity testing after twins are born Fraternal twins already look different from one another, since they are born from two different eggs fertilized with two different sperm, so there's no quick way to determine if they are from different fathers.

Prenatal paternity testing Amniocentesis and CVS are two invasive prenatal tests that are almost never performed for paternity testing. Learn more about twins: Signs you're having twins or multiples Likelihood of twins: Can you increase your chances?

Sources BabyCenter's editorial team is committed to providing the most helpful and trustworthy pregnancy and parenting information in the world. Featured video. Strange but true: Getting pregnant when you're already pregnant. Mixed-race twins: one black, one white. Can a baby have two sets of DNA?



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